LCP: it fills what nothing else will
LCP’s molecules are already ordered in the melt, and they slide past each other under shear, so its viscosity drops sharply in a thin, fast-moving channel. That is what lets it fill very thin walls over a long flow length, and why connectors and thin-walled micro parts are made from it. It also freezes fast, so it fills quickly or it does not fill at all.
LCP: the weld line is the weak point
The same ordering that makes LCP flow makes its weld lines weak. Where two flow fronts meet, the ordered structures butt against each other instead of entangling, so a weld line in LCP is far weaker than the bulk material. Any hole, pin or insert creates one behind it. Gate position decides where those seams land, and on an LCP part that decision decides whether it survives assembly.
LCP: near-zero shrink one way, not the other
Along the flow, LCP barely shrinks at all. Across it, it shrinks noticeably more. That is excellent for a long, slender dimension that runs with the flow, and a trap for one that runs across it. On an LCP part, the question is not “what is the shrink” but “which way does this dimension run relative to the gate.”
COC: clear, dry and clean
COC is amorphous and absorbs almost no water, so it holds its dimensions and its optical properties in wet service. It is used for microfluidic chips, diagnostic cartridges and drug-delivery parts because it combines glass-like clarity with low extractables and low autofluorescence. Its sensitivities are the ones a clear part always has: flow lines and molded-in stress show as birefringence, and a scratch on the cavity is a scratch on every part.
COC: channels are a tooling problem
A microfluidic channel is a raised rib on the cavity steel, and its width, depth and wall angle are set there. Whether the plastic replicates it faithfully depends on the melt reaching the bottom of the feature before it freezes, which is a mold-temperature and injection-speed question more than a pressure one. The cavity is where channel dimensions are won, which is why the steel is cut and measured to a tighter figure than the part.